Two people have been taken to hospital and more than a hundred homes evacuated as firefighters worked through the night to contain a massive inferno at a Melbourne recycling plant.
The blaze broke out at the Coolaroo SKM Recycling factory on Thursday morning and the Metropolitan Fire Brigade has managed to contain the blaze within the factory perimeter.
Ambulance Victoria confirmed five people were assessed by paramedics at the evacuation centre set up at Broadmeadows Aquatic Leisure Centre and on Friday two men were taken to hospital with respiratory related illnesses.
Both men are in a stable condition.
Incident controller Brendan Angwin told the Nine Network there were still 160 personnel on the scene and 35 firet rucks.
"We have had some success around the edges of it but it is all dependent on the wind and weather and how we can get to battle that," he said.
Factory staff and nearby businesses were evacuated earlier on Thursday and are unlikely to be able to return for several days.
The toxic smoke is being caused by the burning cardboard, paper and plastic at the factory.
A watch and act warning for smoke remains in place for a number of suburbs across Melbourne's north including Broadmeadows, Campbellfield, Fawkner, Glenroy, Jacana, Westmeadows.
Residents in neighbouring suburbs should shut off air-conditioning and heating and close windows and doors.
It is the fourth time the factory has caught on fire in recent months, with other blazes in February, June and on Wednesday night.