Three men have lost their life, while another fights for his in the Townsville Hospital.
Police say a car left the road near bridge 15, Tully Gorge Road and was seen by a passing motorist upside down and semi- submerged.
The man attempted to free all men in the car, but three of them sadly died at the scene.
Cairns Forensic Crash Unit will continue their investigations today.
If you have any information for police, contact PoliceLink on 131 444.