A serious crash involving three cars and one truck is causing significant delays on Lane Cove Road and Ryde Road at the M2 Interchange in Macquarie Park.
Only one lane in each direction remains open on Lane Cove Rd at the M2.
Emergency services and incident response crews are working to release a trapped occupant.
There has also been a significant spillage of cement bags at this location.
The M2 is not impacted.
Motorists travelling on Lane Cove Road via the M2 overpass are advised to avoid the area, or expect significant delays.