Mildura Police are appealing to the public for any details on missing 16-year-old Nichola Kirkpatrick.
The 16-year-old was last seen at a bus stop on Seventh Street in Mildura.
Investigators believe she may be travelling to Cootamundra New South Wales, possibly with a male companion.
It is believed she may have boarded a second bus to Canberra about 2.50 pm, arriving there at 5.40 pm.
Nichola is described as 157 centimetres tall, medium build, blue eyes, with blonde and red hair; which is often tied back in a bun.
There are concerns for her welfare due to her age and the fact that she has a medical condition.
Anyone with information on Nicola's whereabouts is urged to call Mildura Police Station on (03) 5018 5300.
A photo of Nichola has been released below: