A man has died following a collision in Pakenham this morning.
Police say the 28-year-old motorcyclist was travelling west bound on Princes Highway when a dark grey Mitsubishi Outlander travelling east performed a u-turn at Ahern Road and collided with the motorcycle about 6.50am.
The man was airlifted with life threatening injuries but died in hospital.
Major Collision Investigation Unit detectives arrested the 22-year-old driver and she is currently in police custody.
Investigators are appealing for anyone who saw the black and red Yamaha R1 travelling on Princes Highway prior to collision or who may have dash cam footage to contact Crime Stoppers on 1800 333 000 or file a confidential report at www.crimestoppersvic.com.au