Police and emergency services have responded to a crash in Millicent.
At around 11am yesterday, officers were called to the Princes Highway near Mullins Lane after reports that a motorcyclist had crashed.
No other vehicle was involved.
The 59-year-old rider from the State's South-East was treated by paramedics, but has sadly died.
Officials are asking motorists to avoid the area as Major Crashes investigates the causes of the incident.