A crime scene has been set up at a home in Woolloongabba after a man was shot at his front door.
Police believe a 27-year-old man had gotten into an argument with a number of people outside his Heaslop Street home just before 1am, when he was shot in the leg, reportedly multiple times.
The injured man was rushed to the PA Hospital with serious injuries, while the gunman fled the scene.
Inspector Steve Flori said the investigation is still in its early days, but they believe it was a targeted attack.
"There is someone in our community who knows who has done this, if you do know who has done this call Crimestoppers. You can do so anonymously and we'll accept that information and try and get these dangerous criminals off the streets," he said speaking to Nine News.